HISTOPATHOLOGICAL CHANGES OF MICE INJECTED WITH PLAGUE LIVE VACCINE STRAIN EV

Histopathological changes of mice injected with plague live vaccine strain EV.

The virulence and immunogenicity (protectivity) of an attenuated live strain of Paeteurella pestis, EV, were examined in mice. When injected subcutaneously at a dose of 106 bacilli, the organisms survived at the injection site for as long as one week though the population decreased gradually. A small number of EV was recovered from the spleen, liver and kidneys from the second to the fifth days...

Experimental study of a further attenuated live measles vaccine of the Sugiyama strain in Iran

Host Iron Nutritional Immunity Induced by a Live Yersinia pestis Vaccine Strain Is Associated with Immediate Protection against Plague

Prompt and effective elicitation of protective immunity is highly relevant for cases of rapidly deteriorating fatal diseases, such as plague, which is caused by Yersinia pestis. Here, we assessed the potential of a live vaccine to induce rapid protection against this infection. We demonstrated that the Y. pestis EV76 live vaccine protected mice against an immediate lethal challenge, limiting th...

Histopathological changes and biochemical analysis of sulfadiazine injected in egg in chicken embryo pectoral muscles

This study aimed to investigate the effects of different doses of sulfadiazine on embryonic chicken pectoral muscles. In total, 100 fertile eggs were obtained and divided into five groups of control (no injection) and sulfadiazine injection at doses of 2, 10, 30, and 70 mg/kg. After hatching, pectoral muscle tissues were harvested from the newly hatched chickens for histopathological examinatio...

Histopathological and Enzymatic Changes in Liver of Mice Treated with Tricyclazole

ABSTRACT           Background and objectives: Tricyclazole (TCZ) is a member of triazole fungicides, which might cause damage in living systems. This study was carried out to examine effects of TCZ on liver tissues and level of liver enzymes.             Methods: Forty mice were randomly divide...